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. 2025 Dec 31;16:624. doi: 10.1038/s41598-025-31771-y

Table 2.

Demographic data and comparative studies between the control and sepsis patient groups regarding MPO, CIT-HIST-H3 levels, and other laboratory investigations.

Parameters Control group Sepsis patient group P-value
No. = 80 No. = 138
Age Mean ± SD 54.8 ± 18.34 53.93 ± 18.45 0.736
Range 16–89 16–89
Sex Male 32 (40.0%) 50 (36.2%) 0.759*
Female 48 (60.0%) 88 (63.8%)
HB g/dL Mean ± SD 13.12 ± 1.23 9.81 ± 1.81 0.000•
Range 11.1–15.8 5.1–17
WBCs (x103/ul) Mean ± SD 7.74 ± 1.58 13.14 ± 4.94 0.000•
Range 4.4–10.5 3.4–32.8
N/L ratio Median (IQR) 2.19(1.19–3.09) 8.7(6.19–14.47) 0.000≠
Range 0.68–8.9 0.77–115
PLTs (x103/ul) Median (IQR) 264(230–309) 124(66–184) 0.000≠
Range 181–344 2–602
PT (sec) Mean ± SD 13.64 ± 1.66 20.16 ± 9.56 0.017•
Range 10.6–16.6 12.9–70.5
INR Mean ± SD 1.03 ± 0.11 1.84 ± 0.93 0.003•
Range 0.87–1.25 1.13–5.84
PTT (sec) Mean ± SD 33.74 ± 6.46 53.3 ± 29.18 0.050•
Range 20.2–40.7 23.9–140
CRP (< 5 mg/L) Median (IQR) 5 (3.5–9) 103 (43.5–203) 0.000≠
Range 0.3–22.1 15–396
FDPs (< 5 Ug/ml) Median (IQR) 24.3 (12–40)
Range 3–170
D dimer (0-0.55 Ug/ml) Median (IQR) 2.29 (1.7–5)
Range 0.98–7
Fibrinogen (2–4 g/L) Median (IQR) 3.3 (2–5.1)
Range 0.5–9
PCT (up to 0.05 ng/ml) Median (IQR) 12.3 (2–45)
Range 0.05–110
Total Bilirubin mg/dl Median (IQR) 1.3 (1.25–2.1)
Range 0.5–8
Creatinine mg/dl Median (IQR) 1.5 (1.01–2.01)
Range 0.8–5.5
MPO (ng/ml) Median (IQR) 2.01 (0.9–2.8) 73.7 (62.1–84.1) 0.000≠
Range 0.21–3.69 36.4–124.8
CIT-HIST-H3 (ng/ml) Median (IQR) 1.38 (0.81–2.19) 106.3 (66.4–193.3) 0.000≠
Range 0.49–3.62 18.2–376.9
SOFA score Median (IQR)

5 (5–8)
Range 3–17
Overall Mortality rate among the Studied sepsis group 49/138 (35.5%)
Mortality rate among the Studied sepsis group in the initial 7 days 24/138 (17.4%)
Catecholamine infusion rate in the sepsis group 104/138 (75.4%)
Use of mechanical ventilation rate in the sepsis group 80/138 (57.9%)
Extrarenal replacement therapy (RRT) in the sepsis group 5/138 (3.6%)

P-value > 0.05: Non-significant; P-value < 0.05: Significant; P-value < 0.01: Highly significant •: Independent t-test; ≠: Mann-Whitney test, *: Chi-square test.