TABLE 1.
Effects of intranasal prophylaxis with P. carinii-specific MAbs on the outcome of PCP in SCID mice
| Expt | Antibody prepn | No. of mice | No. of P. carinii-positive-micea | No. of P. carinii cells/mouse (log10) |
|---|---|---|---|---|
| 1 | Anti-gpA pool | 5 | 2 | 4.60 ± 0.76b |
| Anti-P. carinii pool | 5 | 0 | <4.06 ± 0.00c | |
| Saline | 5 | 5 | 5.78 ± 0.38 | |
| 2 | 4F11 + 1G4 | 8 | 0 | <4.30 ± 0.00d |
| Anti-30-70-kDa pool | 8 | 3 | 4.59 ± 0.52 | |
| IgM- and IgG-negative control | 8 | 8 | 5.04 ± 0.18 | |
| 3 | 1G4 | 8 | 7 | 5.44 ± 0.64e |
| 4F11 | 8 | 8 | 5.79 ± 1.20 | |
| 4F11(G1) | 8 | 8 | 6.16 ± 1.51 | |
| Anti-30-70-kDa pool | 8 | 8 | 6.43 ± 0.41 | |
| IgM- and IgG-negative control | 8 | 8 | 6.43 ± 1.21 | |
| 4 | 1G4 | 8 | 1 | 3.87 ± 0.32d |
| 4F11 | 7 | 1 | 3.99 ± 0.61d | |
| 4F11(G1) | 7 | 1 | 4.14 ± 1.00b | |
| IgG-negative control | 7 | 7 | 5.05 ± 0.55d | |
| IgM-negative control | 6 | 6 | 6.19 ± 0.39 |
a
Number of organisms detectable by microscopy.
b
P ≤ 0.03 compared to value for IgG control.
c
P = 0.008.
d
P < 0.001 compared to value for IgM control.
e
P = 0.01 compared to values obtained with control MAbs.