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. 2026 Jan 1;16(6):2952–2983. doi: 10.7150/thno.124189

Figure 8.

Figure 8

In vivo antitumor effects of MCT-NE#9. (A) Tumor volume of each mouse for 21 days of treatment. Values are expressed as mean ± SEM (n = 10 per group). (B) Isolated tumor weight after 21 days. Values are expressed as mean ± SEM (n = 10 per group). (C) Photographs of tumors isolated from each group on day 21. Scale bar: 10 mm. (D) Quantification of CD71 in cancer cells. (E) Quantification of LPO in cancer cells. (F) Quantification of CD47 in cancer cells. (G) Immunohistochemical staining of CD71 and GPX4 in tumor tissues from control, MTD, and MCT-NE#9 groups. Values are shown as mean ± SEM (n = 10). (H) Scatter plot of ferroptosis-related gene expression in MCT-NE#9 versus control. Key markers (Tmem164, Dhcr7, SLC7A11, Sc5d, and GPX4) are highlighted. (I) Heatmap showing ferroptosis-related gene expression across control, MTD, and MCT-NE#9 groups. Red indicates upregulation, and blue indicates downregulation (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.