Skip to main content
PMC home page
Canadian Journal of Comparative Medicine logoLink to Canadian Journal of Comparative Medicine
. 1977 Jan;41(1):117–121.

Interferon inducers and foot-and-mouth disease vaccines: influence of two synthetic polynucleotides on antibody response and immunity in guinea pigs and swine.

H R Cunliffe, J Y Richmond, C H Campbell
PMCID: PMC1277702  PMID: 188530

Abstract

Polyriboadenylic-polybouridylic acid enhanced the immunological response of guinea pigs to aqueous foot-and-mouth disease virus vaccine. Polyriboninosinic-polyribocytidylic acid enhanced the early antibody production of swine to oil emulsified foot-and-mouth disease virus vaccine. Polyriboninosinic-polyribocytidylic acid alone did not stimulate resistance to foot-and-mouth disease in swine.

Full text

PDF
117

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Braun W., Nakano M. Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science. 1967 Aug 18;157(3790):819–821. doi: 10.1126/science.157.3790.819. [DOI] [PubMed] [Google Scholar]
  2. Campbell C. H., Richmond J. Y. Enhancement, by two carboxylic acid interferon inducers of resistance stimulated in mice by foot-and-mouth disease vaccine. Infect Immun. 1973 Feb;7(2):199–204. doi: 10.1128/iai.7.2.199-204.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell C. H., Richmond J. Y., McKercher P. D. Studies with divinyl ether-maleic anhydride and foot-and-mouth disease vaccines in swine. Arch Gesamte Virusforsch. 1974;46(3-4):334–340. doi: 10.1007/BF01240075. [DOI] [PubMed] [Google Scholar]
  4. Cowan K. M., Trautman R. Immunochemical studies of foot and mouth disease. I. Complement fixation reactions with isolated antigenic components. J Immunol. 1967 Oct;99(4):729–736. [PubMed] [Google Scholar]
  5. Cunliffe H. R., Graves J. H. Formalin-Treated Foot-and-Mouth Disease Virus: Comparison of Two Adjuvants in Cattle. Can J Comp Med Vet Sci. 1963 Aug;27(8):193–197. [PMC free article] [PubMed] [Google Scholar]
  6. Graves J. H., McKercher P. D., Callis J. J. Foot-and-mouth disease vaccine: influence of the vaccine virus subtype on neutralizing antibody and resistance to disease. Am J Vet Res. 1972 Apr;33(4):765–768. [PubMed] [Google Scholar]
  7. Graves J. H., McKercher P. D., Farris H. E., Jr, Cowan K. M. Early response of cattle and swine to inactivated foot-and-mouth disease vaccine. Res Vet Sci. 1968 Jan;9(1):35–40. [PubMed] [Google Scholar]
  8. HYDE J. L., GRAVES J. H. The comparative titration of foot-and-mouth disease virus inoculated into the tongue and foot pads of guinea pigs. Am J Vet Res. 1963 May;24:642–643. [PubMed] [Google Scholar]
  9. McKercher P. D., Giordano A. R. Foot-and-mouth disease in swine. I. The immune response of swine of chemically-treated and non-treated foot-and-mouth disease virus. Arch Gesamte Virusforsch. 1967;20(1):39–53. doi: 10.1007/BF01245768. [DOI] [PubMed] [Google Scholar]
  10. McVicar J. W., Richmond J. Y., Campbell C. H., Hamilton L. D. Observations of cattle, goats and pigs after administration of synthetic interferon inducers and subsequent exposure to foot and mouth disease virus. Can J Comp Med. 1973 Oct;37(4):362–368. [PMC free article] [PubMed] [Google Scholar]
  11. POLATNICK J., BACHRACH H. L. PRODUCTION AND PURIFICATION OF MILLIGRAM AMOUNTS OF FOOT-AND-MOUTH DISEASE VIRUS FROM BABY HAMSTER KIDNEY CELL CULTURES. Appl Microbiol. 1964 Jul;12:368–373. doi: 10.1128/am.12.4.368-373.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Richmond J. Y., Campbell C. H. Enhancement of primary antigen-specific resistance in infant mice with divinyl ether-maleic anhydride. Infect Immun. 1974 Nov;10(5):1029–1033. doi: 10.1128/iai.10.5.1029-1033.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Richmond J. Y., Hamilton L. D. Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A. 1969 Sep;64(1):81–86. doi: 10.1073/pnas.64.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Richmond J. Y. Mouse Resistance Against Foot-and-Mouth Disease Virus Induced by Injections of Pyran. Infect Immun. 1971 Feb;3(2):249–253. doi: 10.1128/iai.3.2.249-253.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sellers R. F., Herniman K. A., Hawkins C. W. The effect of a synthetic anionic polymer (pyran) on the development of foot-and-mouth disease in guinea-pigs, cattle and pigs. Res Vet Sci. 1972 Jul;13(4):339–341. [PubMed] [Google Scholar]
  16. Wagner G. G., Card J. L., Cowan K. M. Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation. Arch Gesamte Virusforsch. 1970;30(4):343–352. doi: 10.1007/BF01258364. [DOI] [PubMed] [Google Scholar]
  17. Woodhour A. F., Friedman A., Tytell A. A., Hilleman M. R. Hyperpotentiation by synthetic double-stranded RNA of antibody responses to influenza virus vaccine in adjuvant 65. Proc Soc Exp Biol Med. 1969 Jul;131(3):809–817. doi: 10.3181/00379727-131-33983. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES