FIG. 5.

Chemokine and MPO levels in WT and IRF-1 KO mice following inoculation of LPS, PLC, or ETA. WT (open bars) and IRF-1 KO (filled bars) mice were inoculated with either LPS (10 μg/mouse), PLC (0.5 μg/mouse), or ETA (2 μg/mouse). Control mice received vehicle. Mice were sacrificed 6 h after inoculation of LPS or PLC and 24 h after administration of ETA. Chemokine and MPO levels were measured in the lung homogenates. Data are means ± SEM of five mice per group. ∗∗, P < 0.01 versus respective WT by unpaired Student's t test.