TABLE 2.
Inhibition of lung IL-18 levels by ETA
| Dose of ETA (ng/mouse)a | Mean ± SEM of IL-18 (pg/ml) in indicated tissueb
|
||
|---|---|---|---|
| Lungc | Liver | Serum | |
| 0 (control) | 838.5 ± 59.8 | 1,480 ± 140 | 55.3 ± 8.6 |
| 20 | 683.2 ± 40.1* | 1,540 ± 120 | 79.7 ± 7.3 |
| 200 | 449.7 ± 40.7*** | 1,780 ± 70 | 63.7 ± 23.4 |
| 2,000 | 286.1 ± 28.5*** | 1,580 ± 60 | 83.3 ± 18.2 |
a
Groups of three to five mice were inoculated with the indicated doses of ETA. Control mice received vehicle.
b
Lungs and liver were removed 24 h following inoculation, and IL-18 levels were measured in the homogenates. Blood was collected 24 h following inoculation, and serum was prepared.
c
*, P < 0.05; **, P < 0.001 versus respective control by factorial ANOVA.