Fig. 2.

Structural comparison of mMICAL₄₈₉ and PHBH. (A) Topology of mMICAL₄₈₉ (β-strands, arrows; α-helices, cylinders). Domains are colored as in Fig. 1 A. Dotted lines denote unique structural elements. The gray-shaded area is deleted in the human splice isoform MICAL-1B (6); this deletion appears to be incompatible with formation of a stable molecule. (B) Equivalent diagram for PHBH. (C) Solvent-accessible surface of mMICAL₄₈₉ with parts unique to mMICAL₄₈₉ (compared with PHBH) highlighted in violet (orientation is as in Fig. 1 A). (D) Solvent-accessible surface of PHBH (oriented to superpose on mMICAL₄₈₉) with parts unique to PHBH (compared with mMICAL₄₈₉) highlighted in cyan.