Fig. 6.

Domain organization of MICAL. In Upper, the domain structure of murine MICAL-1 is mapped onto a bar representing the linear sequence. The boundaries for the enzymatic (MO) domain (red) are taken from the mMICAL₄₈₉ crystal structure. Boundaries for the CH (blue) and LIM (magenta) domains are defined from sequence alignments with homologous structures. A Src homology 3 (SH3) domain-binding motif is marked in yellow. Two coiled-coil regions are highlighted in orange, and potentially flexible linker regions are indicated by black lines above the bar (region 1, 486-512; region 2, 635-679; region 3, 830-883). Lower shows, to scale, the available structural information: CH domain, LIM domain, SH3 domain-binding motif, and examples of coiled coil (PDB ID codes 1BKR, 1IML, 1N5Z, and 1I84, respectively). Structures are orientated sequentially, with N and C termini marked.