TABLE 1.
Systemic and mucosal antibody responses of mice orally immunized with rPsaA
| Group | Vaccine | No. of mice | Geometric mean concn (ng/ml) ± SEM of:
|
||||
|---|---|---|---|---|---|---|---|
| Serum IgM | Serum IgG | Serum IgA | Lung IgA | Intestine IgA | |||
| 1 | eBSA | 6 | 232.7 ± 10.6 | 17.5 ± 1.1 | 5.7 ± 3.1 | 0.7 ± 0.3 | 0.7 ± 0.2 |
| 2 | nPsaA | 7 | 439.9 ± 8.5 | 59.4 ± 1.4 | 17.1 ± 3.9 | 1.8 ± 0.1 | 2.6 ± 0.1 |
| 3 | ePsaA | 7 | 486.2 ± 12.6 | 73.0 ± 1.7 | 31.9 ± 3.1 | 2.1 ± 0.1 | 3.2 ± 0.3 |
| 4 | nPsaA−CT | 7 | 466.1 ± 23.6 | 72.9 ± 5.3 | 29.0 ± 3.9 | 2.5 ± 0.1 | 3.5 ± 0.3 |
| 5 | ePsaA−CT | 7 | 539.1 ± 13.7 | 187.9 ± 18.1 | 70.8 ± 11.8 | 3.6 ± 0.3 | 3.9 ± 0.4 |
| 6 | nPsaA−CTB | 7 | 407.4 ± 21.8 | 68.2 ± 5.9 | 18.1 ± 0.9 | 1.8 ± 0.2 | 2.8 ± 0.4 |
| 7 | ePsaA−CTB | 7 | 545.3 ± 40.1 | 126.3 ± 15.6 | 57.5 ± 1.9 | 3.9 ± 0.8 | 4.0 ± 0.2 |
| 8 | e(PsaA−CTB)1 | 7 | 1901.0 ± 141.4 | 146.5 ± 68.6 | 118.3 ± 38.9 | 5.3 ± 0.7 | 5.5 ± 0.9 |
| 9 | e(PsaA−CTB)2 | 7 | 1759.9 ± 208.1 | 53.4 ± 23.9 | 135.3 ± 96.7 | 6.0 ± 0.6 | 6.6 ± 0.4 |
| 10 | e(PsaA−CTB)3 | 9 | 1542.2 ± 222.9 | 71.1 ± 24.6 | 366.4 ± 37.6 | 16.6 ± 0.8 | 14.1 ± 1.0 |