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. 2025 Sep 1;26(1):107–120. doi: 10.1007/s40256-025-00743-y

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Threshold effect of cumulative colchicine exposure on the primary outcome. A threshold effect of cumulative exposure was observed on the secondary protection of colchicine against MACE (cumulative colchicine exposure ≥ 90 mg-days: OR 0.66; 95% CI 0.52–0.84 vs <90 mg-days: OR 0.93; 95% CI 0.79–1.09, between-groups difference p = 0.02). CI confidence interval, MACE major adverse cardiovascular events, OR odds ratio