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. 2002 Mar;70(3):1150–1158. doi: 10.1128/IAI.70.3.1150-1158.2002

FIG. 7.

FIG. 7.

Effect of the MEK inhibitor PD98059 on S. flexneri-induced PMN transepithelial migration. (A) S. flexneri 2457T (wild type)-induced PMN transmigration is significantly decreased when the T84 cell monolayer is preincubated with 10 or 50 μM MEK inhibitor PD98059. (B) PMN transmigration induced by S. enterica serovar Typhimurium or fMLP is not affected by PD98059. The data are expressed as the mean and standard deviation of triplicate samples for all conditions tested and represent one of at least three experiments performed with similar results. *, P < 0.05 compared to the 0 μM PD98059 buffer or vehicle control.