FIG. 1.

(A) Both wild-type (solid circles) and RAG1 KO mice (solid squares) lose body weight during the first 24 days of a C. rodentium infection, compared to uninfected wild-type (open circles) and RAG1 KO (open squares) mice. Weight data from one representative experiment out of three are shown. Error bars represent standard errors. Each data point represents average weight data pooled from 10 mice and is expressed as the percentage of the initial body weight. Infected wild-type mice weighed significantly less than uninfected mice from day 2 until day 24 p.i. Infected RAG1 KO mice weighed less than uninfected mice on day 2 and days 14 to 21 p.i. ∗, P < 0.05. (B) Survival of wild-type mice (solid circles) is greater than that of RAG1 KO mice (open circles) over the first 24 days of a C. rodentium infection. Survival data from one representative experiment out of three are shown. Each data point represents the percentage of surviving mice from an initial population of 10 mice.