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. 2002 Apr;70(4):1915–1923. doi: 10.1128/IAI.70.4.1915-1923.2002

TABLE 3.

Protection against a B. abortus 544 challenge provided to BALB/c mice by vaccination with live O:3, O:9, or S19 strainsa

Treatment group (n = 3 or 4) Vaccine injection route Vaccine Vaccination challenge delay (wk) Log10 brucellae in spleen (mean ± SD) at time (wk) postchallenge
Log units of protection at wk
4 8 4 8
1 i.g. O:3 2 4.32 ± 0.17 3.58 ± 0.13 0.13 0.09
2 i.g. O:3(pCI) 2 4.43 ± 0.14 3.55 ± 0.02 0.02 0.12
3 i.g. O:3(pCIBFR) 2 3.96 ± 0.12 2.95 ± 0.16 0.49 0.72
4 i.g. O:3(pCIP39) 2 3.76 ± 0.20 2.80 ± 0.11 0.69 0.87b,c
5 i.g. O:9 2 3.02 ± 0.16 2.52 ± 0.16 1.43b,c 1.15b,c
6 i.g. O:9(pCI) 2 3.15 ± 0.19 2.44 ± 0.13 1.3b,c 1.23b
7 i.g. O:9(pCIBFR) 2 2.81 ± 0.45 2.04 ± 0.10 1.64b 1.63b
8 i.g. O:9(pCIP39) 2 2.03 ± 0.25 1.7 2.22b 1.97b
9 i.g. O:3-O:9 2 2.92 ± 0.07 2.40 ± 0.12 1.53b,c 1.27b
10 i.g. O:3(pCIP39)-O:9 2 2.35 ± 0.02 1.7 2.1b 1.97b
11 i.g. O:3 8 4.27 ± 0.13 3.61 ± 0.02 0.18 0.06
12 i.g. O:3(pCIBFR) 8 4.15 ± 0.07 3.42 ± 0.04 0.30 0.25
13 i.g. O:3(pCIP39) 8 4.03 ± 0.17 3.26 ± 0.03 0.42 0.41
14 i.g. O:9 8 3.19 ± 0.04 2.03 ± 0.16 1.26b,c 1.64b
15 i.g. O:9(pCIBFR) 8 3.08 ± 0.04 1.97 ± 0.18 1.37b,c 1.7b
16 i.g. O:9(pCIP39) 8 2.7 ± 0.25 1.72 ± 0.14 1.75b 1.92b
17 i.g. B19 4 3.67 ± 0.19 2.77 ± 0.22 0.73b,c 0.9b,c
18 i.p. B19 4 2.15 ± 0.15 1.7 2.3b 1.97b
19 i.p. B19 8 1.85 ± 0.15 1.7 2.6b 1.97b
20 i.p. PBS 4.45 ± 0.13 3.67 ± 0.08
a

Groups 1 through 16 were vaccinated with 1 × 108 to 3 × 108 CFU, group 17 was vaccinated with 1 × 109 CFU, and groups 18 and 19 were vaccinated with 5 × 104 CFU. All groups were challenged i.p. with 5 × 104 CFU of B. abortus 544.

b

Statistically different from the unvaccinated control (P = 0.05).

c

Statistically different from the B19 i.p. vaccinated control (P = 0.05).