TABLE 4.
Characteristics of HV regions of MS11 Opa proteins
| Protein | CEACAM recognitiona | HV-1
|
HV-2
|
||||
|---|---|---|---|---|---|---|---|
| No. of residuesb
|
Net chargec | No. of residues
|
Net charge | ||||
| K, R, H | D, E | K, R, H | D, E | ||||
| OpaB | 1,3,6, CEA | 6 | 2 | +4 | 10 | 4 | +4.5 |
| OpaC | 1,3,6, CEA | 8 | 3 | +4.5 | 13 | 4 | +8 |
| OpaI | 1,3,6, CEA | 7 | 3 | +4 | 7 | 4 | +2.5 |
| OpaD | 1, CEA | 6 | 5 | +1 | 9 | 3 | +4.5 |
| OpaF | 1, CEA | 8 | 2 | +5.5 | 8 | 2 | +4.5 |
| OpaK | 1 | 6 | 3 | +2.5 | 8 | 2 | +4.5 |
| OpaA | None | 9 | 1 | +7 | 10 | 3 | +6 |
a
1,3,6, CEA, recognizes CEACAM1, -3, and -6 and CEA; 1, CEA, recognizes CEACAM1 and CEA; 1, recognizes CEACAM1 weakly; none, no recognition of any CEACAM family member.
b
Number of basic (K, R, H) or acidic (D, E) residues present in the HV region.
c
Net charge of the HV region, counting K and R as +1, H as +0.5, and D and E as −1 as described by Swanson (36).