FIG. 2.

Representative micrographs of guinea pig lungs, showing the reduction in granulomatous inflammation in the BCG-vaccinated (A) and pCMV-83-vaccinated (B) groups compared with the pVR1020-85A-vaccinated group (C) and the PBS control (D). Vaccination with BCG or pCMV-83, but not vaccination with pVR1020-85A, reduced both the number and the size of the granulomas, as reflected in the pathology scores shown in Table 1. The sections were given the following scores for granuloma size: panel A, 1.00; panel B, 1.00; panel C, 2.00; and panel D, 2.00. These photographs also demonstrate the marked reductions in the numbers of lymphocytes observed in the three vaccinated groups compared with the control. The sections were given the following scores for lymphocytic infiltration: panel A, 1.00; panel B, 0.67; panel C, 1.00; and panel D, 1.67. Bar = 400 μm.