TABLE 2.
Vaccine antigen-specific ASC responses in volunteers receiving the LT/CS6 combination (n = 19)
| ASC type | No. of responders (%)a | Median no. of ASCs/106 PBMC (range)b |
|---|---|---|
| Anti-LT IgG | 15 (79) | 9 (1.3-49) |
| Anti-LT IgA | 7 (37) | 2.4 (1.3-46) |
| Anti-CS6 IgG | 7 (37) | 6 (1.7-77) |
| Anti-CS6 IgA | 8 (42) | 2.4 (1.7-12) |
a
A positive ASC response was defined as a ≥2-fold increase over baseline value of the ASCs per 106 PBMC, when the number of ASCs was ≥0.5 per 106 PBMC in the baseline sample. If the number of preimmune ASCs was less than 0.5 per 106 PBMC, a value of >1.0 per 106 PBMC after dosing was considered a positive response.
b
Only positive responses were included when calculating the median number of ASCs (range).