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Reverse cumulative distribution plot of the fold increase in IIIPS-specific IgG in sera 8 weeks after immunization with unconjugated IIIPS (n = 30) (upper panel) or III-TT conjugate vaccine (n = 30) (lower panel). The proportions of vaccine-induced IgG that recognized native IIIPS (solid lines) or Pn14 PS (i.e., desialylated IIIPS) (dotted lines) are indicated.
