TABLE 2.
Correlation of concentrations of vaccine-induced antibodies binding to IIIPS in solution (RABA) and those binding to native GBS IIIPS and desialylated IIIPS (i.e., Pn14 PS) supported by solid surfaces (ELISAs)
| Vaccinee group | No. of samples tested | Results with indicated ELISA coating antigena
|
||
|---|---|---|---|---|
| III-HSA | IIIPS + mHSA | Pn14 PSb | ||
| IIIPS | 30 | 0.94 (0.88-0.97) | 0.79 (0.59-0.90) | 0.74 (0.52-0.87) |
| III-TT | 30 | 0.97 (0.92-0.98) | 0.87 (0.74-0.94) | 0.55 (0.23-0.77) |
| All | 60 | 0.96 (0.93-0.98) | 0.82 (0.71-0.89) | 0.67 (0.49-0.79) |
a
Values are given as Spearman rank correlation coefficients between concentrations of GBS IIIPS-specific immunoglobulin in sera quantitated by the RABA and those quantitated by the ELISAs. The values in parentheses are the 95% confidence intervals. All correlations were statistically significant (P < 0.002).
b
Immunochemically identical to the GBS IIIPS core antigen.