TABLE 1.
K. pneumoniae pneumonia in micea
| Strain | Phenotype | No. of animals | No. of expts | Mean inoculum (range) | Mean lung wt (g) | Mean log CFU/g | No. blood or spleen culture positive/ total no. (%) | No. dead/total no. (%) |
|---|---|---|---|---|---|---|---|---|
| 52145R | Wild type | 36 | 4 | 1.3 × 107 (3.0 × 106 to 2.7 × 107) | 0.29 ± 0.11 | 6.11 | 17/32b (52) | 21/36 (58.3) |
| 52K10 | CPS− | 18 | 2 | 2.0 × 107 (1.0 × 105 to 6 × 107) | 0.15 ± 0.06 | 0.41 | 0/18 (0) | 0/18 (0) |
| 52O21 | LPS O− | 22 | 2 | 7.9 × 106 (7.8 × 106 to 8.0 × 106) | 0.41 ± 0.16 | 6.61 | 10/18b (55.6) | 14/22 (60.7) |
a
P < 0.01 for all comparisons (lung weight, log CFU per gram of lung, blood or spleen culture positive, and mortality) between the unencapsulated mutant and the wild type or the LPS O− mutant, two-tailed t test.
b
Blood or spleen culture was not obtained from four animals.