TABLE 1.

Monoclonal antibodies against human IL-6 and IL-11 eliminate T-cell recovery by coculture of gingival fibroblasts and Jurkat cells^a

Coculture	Treatment	% DNA fragmentation (meanb ± SD)
Jur + Jur	BA	28.9 ± 1.9
Jur + F41-G	BA	20.1 ± 1.8
Jur + F41-G	BA + anti-IL-6	27.6 ± 1.2c
Jur + F41-G	BA + anti-IL-11	27.2 ± 2.0c
Jur + F41-G	BA + anti-IL-8	19.4 ± 2.1
Jur + F41-G	BA + anti-IL-6, -IL-11, -IL-8	29.3 ± 1.9c

^aJurkat cells were indirectly cocultured with F41-G cells that had been presensitized with 5 mM butyric acid (BA), using pore-filled cell culture insert (intercup), for 1 h in the absence or presence of neutralizing MAbs (10 μg/ml) against IL-6, IL-8, and IL-11 and then cultured with 5 mM butyric acid for 21 h. Harvested cells were assayed by the DPA assay.

^bMean of three experiments carried out in triplicate.

^cSignificantly different from the corresponding MAb-free butyric acid values at a P of <0.05.