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Induction of mucosal tolerance to SEA requires production of IL-10. IL-10−/− mice (n = 10) were given OVA or SEA three times i.n. and challenged with SEA-LPS. Data are expressed as the percentage of OVA-administered (▪) (n = 6) and SEA-tolerized (□) (n = 6) IL-10−/− mice that survived the first 20 h post-SEA challenge. This experiment was repeated one more time with similar results.
