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Chemical structure of the LCP-J8 construct. Four identical peptide J8 sequences were synthesized directly onto the two amino groups of each lysine (Lys) of a branched polylysine core. The lipophilic anchor of the LCP-J8 construct contains three 2-amino-dodecanoic lipoamino acids (shown as branched alkyl side chains) attached to the polylysine core, with one glycine amino acid spacer between the resin and the first lipoamino acid and a second between the second and third lipoamino acids.
