TABLE 1.
Summary of the breeding data from the congenic mBD-1−/− colonya
| Mating type | Total no. of offspring | Litter size | No. (%) of:
|
No. (%) with genotype:
|
|||
|---|---|---|---|---|---|---|---|
| Females | Males | wt | het | KO | |||
| het × het | 275 | 6.7 ± 1.7 | 135 (49.1) | 140 (50.9) | 70 (25.4) | 155 (56.5) | 50 (18.2) |
| wt × wt | 124 | 5.6 ± 2.4 | 65 (52.4) | 59 (47.6) | 124 (100) | ||
| KO × KO | 133 | 7.0 ± 1.8 | 70 (52.6) | 63 (47.4) | 133 (100) | ||
a
het, heterozygous; wt, wild type; KO, knockout. Significantly fewer mBD-1−/− mice were obtained from heterozygote parents than expected according to Mendelian inheritance (Pearson chi-square goodness-of-fit test, 1:2:1 distribution; P = 0.025). However, the fertility of homozygous parents of the mBD-1+/+ and mBD-1−/− genotypes was found to be indistinguishable.