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. 2025 Dec 25;59:161–173. doi: 10.1016/j.bioactmat.2025.12.037

Fig. 3.

Fig. 3

Multimodal oxygen modulation via SOD-CPO cascade catalytic circuit (a) Schematic cascade enzymatic reaction enhanced PDT via ROS regulation of SOD-modulated O2 and CPO/PDT-modulated 1O2 production. (b) The fluorescence changes of O2 probe (Ru(dpp)3)Cl2 over time. (c) The fluorescence changes of H2O2 probe ADHP over time. (d) The fluorescence changes of 1O2 probe SOSG over time. (e) The intensity of 1O2 at 15 min of the X/XO, CPO@Gel and SOD-CPO@Gel reaction system. (f) Activity retention of loaded SOD in 2 weeks. (g) Activity retention of loaded CPO in 2 weeks. (h) The fluorescence spectra of H2O2 generated by SOD@Gel over time. (i) The fluorescence spectra of 1O2 generated by SOD-CPO@Gel over time. (j) The concentrations of H2O2 and 1O2 produced by the SOD-CPO cascade circuit.