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5. Synthesis of 2-Methyl-6-(het)aryl
7-Deazapurine Ribonucleoside Bisphosphonates
.
aReaction
conditions: a) R-B(OH)2, Na2CO3, Pd(OAc)2, TPPTS, H2O/MeCN, 80–100
°C, 1 h.
b) 1: methylene bis(phosphonic dichloride), PO(OMe)3, 0
°C, 3 h; 2: H2O, 22 °C, 1 h.