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a Reaction conditions: a) 0.5 M NaOMe, 60 °C, 16 h; b) MeNH2 (33% in EtOH), TEA, 80 °C, 16 h; c) 1: methylene bis(phosphonic dichloride), PO(OMe)3, 0 °C, 3 h; 2: H2O, 22 °C, 1 h.
