Table 2.

Hepatic expression of genes encoding differentially abundant proteins in hepatic steatosis and MASH

Gene	HS vs. CTL				MASH vs. CTL				MASH vs. HS
	PRJNA512027		Meta-analysis		PRJNA512027		Meta-analysis		PRJNA512027		Meta-analysis
	z-score	FDR	z-score	FDR	z-score	FDR	z-score	FDR	z-score	FDR	z-score	FDR
AFM	1.971	5.95E − 01	2.074	1.74E − 01	1.819	1.49E − 01	2.076	1.21E − 01	− 0.111	9.45E − 01	2.492	3.69E − 02
APOA1	0.167	9.88E − 01	1.093	5.31E − 01	− 0.515	1.69E − 05	0.312	8.64E − 01	− 5.909	< 1.0E − 08	− 0.853	5.21E − 01
C4A	− 1.043	8.41E − 01	− 1.471	3.71E − 01	− 0.471	7.52E − 01	− 1.968	1.45E − 01	0.663	6.38E − 01	− 1.085	4.01E − 01
COL18A1	0.268	9.81E − 01	0.945	6.00E − 01	− 4.606	7.78E − 05	− 0.381	8.29E − 01	− 5.711	4.58E − 07	− 1.893	1.20E − 01
INHBE	2.676	3.49E − 01	4.115	2.01E − 03	3.678	1.59E − 03	4.587	1.05E − 04	0.388	7.94E − 01	3.867	8.82E − 04
PRG4	1.367	7.73E − 01	− 0.195	9.27E − 01	4.111	3.99E − 04	0.135	9.45E − 01	3.271	4.69E − 03	1.552	2.12E − 01

Gene expression data was extracted from PRJNA512027 (n = 192) [59] and our previously published meta-analysis of transcriptomic datasets (n = 1058) [60]. HS hepatic steatosis, CTL control (healthy liver), MASH metabolic dysfunction-associated steatohepatitis

Statistically significant results are shown in boldface