Table 2. Changes related to transition in women with osteopenia compared with those with normal BMDs at baseline and subsequent fracture occurrence.

Initial DXA score		Normal (n = 396)	Mild (n = 277)	Moderate (n = 281)	Severe (n = 196)
Transition to lower categories (n = 399)		101 (25.5)	104 (37.5)	117 (41.6)	77 (39.3)
	P	-	0.001	< 0.001	0.001
Transition to osteoporosis (n = 116)		1 (0.01)	10 (3.6)	28 (9.9)	77 (39.3)
	P a	-	< 0.001	< 0.001	< 0.001
Individuals fracturing (n = 199)		38 (9.6)	47 (17.0)	59 (21.0)	55 (28.1)
	P	-	0.005	< 0.001	< 0.001
Total fractures (n = 239)		43 (10.9)	55 (19.5)	74 (26.3)	67 (34.2)
	P	-	0.001	< 0.001	< 0.001
Major fractures (n = 64)		12 (3.0)	10 (3.6)	22 (7.83)	20 (10.2)
	P	-	0.68	0.005	< 0.001
Hip fractures (n = 22)		2 (0.5)	4 (1.44)	7 (2.49)	9 (4.59)
	P	-	0.24	0.04	0.001
Vertebral fractures (n = 31)		7 (1.77)	4 (1.44)	12 (4.27)	8 (4.08)
	P	-	1.00	0.052	0.092
Intermediate fractures (n = 127)		24 (6.06)	34 (12.3)	38 (13.9)	30 (15.3)
	P	-	0.005	0.001	< 0.001
Minor fractures (n = 48)		7 (1.76)	11 (3.97)	13 (4.63)	17 (8.67)
	P	-	0.081	0.030	< 0.001

Data are presented as number (%). Values in parentheses represent the percentage of the total population in each category.

BMD: bone mineral density, DXA: dual-energy X-ray absorptiometry, -: not available.

^aFisher exact test.

Reproduced from the article of Pfister et al. (South Med J 2016; 109: 118-23) [9] with original copyright holder’s permission.