Table 4. Drugs approved by the U.S. Food and Drug Administration for prevention and treatment of postmenopausal osteoporosisa.
| Drug | Postmenopausal osteoporosis | |
|---|---|---|
| Prevention | Treatment | |
| Abaloparatide (Tymlos) | - | 80 µg SQ daily |
| Alendronate (Fosamax) | 5 mg PO daily | 10 mg PO daily |
| 35 mg PO weekly | 70 mg PO weeklyb | |
| 70 mg + Dc | ||
| Calcitonin (Miacalcin, Fortical) | - | 200 IU intranasally once daily or 100 IU SQ qod |
| Denosumab (Prolia) | - | 60 mg SQ every 6 months |
| Estrogen (multiple formulations; estrogenbazodoxifene) | Multiple regimens | - |
| Ibandronate (Boniva, generic form) | 2.5 mg PO daily | 2.5 mg PO daily |
| 150 mg PO monthly | 150 mg PO monthly | |
| 3 mg IV every 3 months | ||
| Raloxifene (Evista) | 60 mg PO daily | 60 mg PO daily |
| Risedronate (Actonel, Atelvia, generic form)d | 5 mg PO daily | 5 mg PO daily |
| 35 mg PO weekly | 35 mg PO weekly | |
| 150 mg PO monthly | 150 mg PO monthly | |
| Romosozumab (Evenity) | - | 210 mg SQ monthly |
| Teriparatide (Forteo) | - | 20 µg SQ daily |
| Zoledronate (Reclast, generic infusion form) | 5 mg IV every 2nd year | 5 mg IV once yearly |
IV: intravenously, PO: orally, qod: every other day, SQ: subcutaneously, -: not available.
aPlease review the package inserts for specific prescribing information. bFosamax 70 mg is available as both a tablet and a unit dose liquid. Alendronate (generic Fosamax) is available. cFosamax Plus D is a tablet containing 70 mg of alendronate and 2,800 IU or 5,600 IU of vitamin D for weekly administration. dRisedronate 150 mg once monthly tablet is available.
Reproduced from the article of Camacho et al. (Endocr Pract 2020; 26: 1-46) [11].