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. 2002 Jun;70(6):3287–3289. doi: 10.1128/IAI.70.6.3287-3289.2002

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Copyright © 2002, American Society for Microbiology

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FIG. 1. — (A to C) Median survival of vaccinated mice after intranasal infection with C. immitis. Vaccinations were adjuvant only (open symbols), 0.5 μg of rAg2/PRA (solid inverted triangle), 1.0 μg of rAg2/PRA (solid circles), 5.0 μg of rAg2/PRA (solid upright triangle), or 1.0 mg of whole killed spherules (solid squares). Each point indicates results from groups ranging from 10 to 14 animals. Each asterisk indicates a significant difference (P < 0.05) between a specific group of animals receiving rAg2/PRA as compared to a group administered the same number of arthroconidia, but which received adjuvant without rAg2/PRA. (A) BALB/c mice vaccinated subcutaneously. (B) C57BL/6 mice vaccinated subcutaneously. (C) BALB/c mice vaccinated intranasally. (D) BALB/c mice vaccinated with whole killed spherules.