TABLE 4.
In vivo IgG Abs relative to in vitro IgG Abs to conserved and polymorphic P. falciparum Ags in donors immune to P. falciparum
| Status of immune donors | No. of Ag-specific IgG responses in individual donor plasma and PBMC culture supernatants
|
||||||
|---|---|---|---|---|---|---|---|
| MSP119 | R23 | PfEB200 | MSP2-2CH4 | MSP1 block 2-RO33 | MSP1 block 2-K1 | MSP1 block 2-MAD20 | |
| Plasma positive, culture positivea | 9 | 7 | 1 | 4 | 4 | 3 | 2 |
| Plasma positive, culture negativea | 2 | 4 | 9 | 3 | 2 | 4 | 2 |
| Plasma negative, culture negative | 1 | 3 | 4 | 8 | 8 | 5 | 10 |
| Plasma negative, culture positive | 3 | 1 | 1 | 0 | 1 | 3 | 1 |
a
Plasma positive irrespective of the isotype responses in plasma.