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Modeled steady-state A2E concentration in the perifoveal retinal pigment epithelium cell, [A2Ess]RPE, as a function of age assuming that each A2E molecule is largely photo-oxidized by 1O2 generated within the lipofuscin granule. Phakic eye (○); addition of vermilion sunglasses for ambient conditions ≥200 cd/m2 in phakic eye before 70 (♦) and after implantation of clear UV-absorbing IOL at 70 (⋄); clear IOL implanted at age 70 (▵); and the yellow IOL implanted at age 70 (•).
