Table 9.
Structural outcome at nine months for infants with bilateral high-risk prethreshold retinopathy of prematurity by icrop category and rm-rop2 risk*
| Icrop classification |
Discordant pairs |
|||||
|---|---|---|---|---|---|---|
| Zone | Stage | Plus disease | Eyes treated at high-risk prethreshold | Conventionally managed eyes | A† | B‡ |
| I | 3 | Yes or No | 27 (29.6) | 27 (55.6) | 8 | 1 |
| I | 1 or 2 | Yes | 9 (22.2) | 9 (22.2) | 0 | 0 |
| I | 1 or 2 | No | 75 (2.7) | 75 (9.3) | 6 | 1 |
| II | 3 | Yes | 109 (7.3) | 110 (10.9) | 6 | 3 |
| II | 3 | No | 3 (0) | 3 (0) | 0 | 0 |
| II | 2 | Yes | 34 (20.6) | 34 (20.6) | 1 | 1 |
| RM-ROP2 risk | ||||||
| 0.15 to <0.30 | 109 (5.5) | 109 (7.3) | 4 | 2 | ||
| 0.30 to <0.45 | 74 (9.5) | 74 (17.6) | 7 | 1 | ||
| 0.45 | 81 (18.5) | 82(30.5) | 12 | 3 | ||
ICROP, International Classification of Retinopathy of Prematurity20; RM-ROP2,7 a risk analysis program based on natural history data from the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity Study.
Data are presented as number (percentage unfavorable) unless otherwise indicated. High risk was 0.15 or greater. Plus disease was defined as a degree of dilation and tortuosity of the posterior retinal blood vessels meeting or exceeding that of a standard photograph. Data include only those eyes for which structural outcome was able to be graded.
For group A, earlier treated eyes had a favorable outcome, and conventionally managed eyes had an unfavorable outcome.
For group B, earlier treated eyes had an unfavorable outcome, and conventionally managed eyes had a favorable outcome.