Figure 1.

Effect of latrunculin B (LAT-B) on intraocular pressure (IOP) in monkeys. 0.005% (A) or 0.01% (B) LAT-B and vehicle were administered to opposite eyes of monkeys topically twice daily for 4.5 days. IOP was measured before and after the first (on day 1) and ninth (on day 5) treatment. The same eyes of the same monkeys were treated with the drug in the two-dose studies, and the higher-dose experiment was conducted the week immediately following the lower-dose experiment, with only 2 days’ drug-free interval between studies. IOP before the first treatment in each study was used as a baseline. Data are mean ± SEM mm Hg for n animals. IOP difference between eyes corrected for baseline was tested for differences ≠ 0.0 by the two-tailed paired t test: *P < .01; †P < .005; ‡P < .001.