TABLE 2.
AO in RSV-infected mice treated with different anti-RSV monoclonal antibodies
| Mouse group | Airway obstructiona
|
||||
|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | |
| Uninfected controls | 0.52 (0.48-0.58)* | 0.52 (0.47-0.63)* | 0.49 (0.45-0.59)* | 0.52 (0.47-0.57)* | 0.50 (0.47-0.57)* |
| RSV infected, untreated | 1.77 (1.62-2.43) | 0.76 (0.61-1.32) | 0.70 (0.64-0.83) | 0.67 (0.61-0.71) | 1.11 (1.01-2.03) |
| RSV Pvz −24 h | 1.49 (1.13-1.96) | 0.65 (0.60-0.80) | 0.45 (0.44-0.48)* | 0.53 (0.45-0.58)* | 0.59 (0.55-0.75)* |
| RSV MEDI-524 −24 h | 0.73 (0.61-1.02)* | 0.58 (0.54-0.64)* | 0.52 (0.49-0.66) | 0.54 (0.47-0.57)* | 0.55 (0.52-0.61)* |
| RSV Pvz +48 h | 1.77 (1.09-2.71) | 0.62 (0.53-0.89) | 0.54 (0.50-0.57)* | 0.57 (0.52-0.62) | 1.08 (0.91-1.30) |
| RSV MEDI-524 +48 h | 1.67 (1.07-2.85) | 0.57 (0.55-0.94) | 0.55 (0.51-0.61) | 0.57 (0.52-0.62) | 0.99 (0.83-1.65) |
a
Values represent basal Penh as a measurement of airway obstruction. Penh values are shown as medians and 25th to 75th percentiles. *, P of <0.001 for comparison between RSV-infected untreated mice and the other regimens (n = 12 to 16 per group).