FIG. 4.

Effects of mouse-type mutations in huCCR5 on entry inhibition of pseudotyped reporter virus by TAK-220 and TAK-779. U87-CD4 cells transiently expressing wild-type huCCR5 or huCCR5 mutants were infected as described in Fig. 2A except for the presence or absence of CCR5 antagonists (TAK-220 or TAK-779) at the concentrations indicated. Results are expressed as in Fig. 3.