FIG. 1.

Dose response to Cpl-1 in rats infected with the multidrug-resistant S. pneumoniae WB4. (A) “Low-continuous infusion” (bolus of 10 mg/kg, followed by a continuous infusion of 5 mg/kg/h for 6 h). (B) “High-continuous infusion” (bolus of 250 mg/kg, followed by continuous infusion of 250 mg/kg/h for 6 h). Each black circle corresponds to a single animal. Dashed lines represent the median bacterial densities. Solid black lines at the bottom of the columns indicate the bacterial detection limit. Values that were significantly different from the values for controls at treatment onset (P < 0.05) are indicated by asterisks.