TABLE 3.
Fosfomycin in abscess fluid after a single intravenous dose of 8 g (n = 13)a
| Parameter | Mean ± SD | Median | Minimum | Maximum |
|---|---|---|---|---|
| Aa/Va ratio (cm−1) | 2.1 ± 2.1 | 1.2 | 0.5 | 8.3 |
| ti (h) | 1.9 ± 1.1 | 1.7 | 0.3 | 3.7 |
| Ca (ti) (mg · liter−1) | 43 ± 57 | 12 | <LOD | 168 |
| P (cm · s−1) | 2.1 × 10−4 ± 3.6 × 10−4 | 7.0 × 10−5 | 2.0 × 10−9 | 1.3 × 10−3 |
| Tmax,a (h) | 10.5 ± 7.8b | 9.3 | 2.1 | 51.2 |
| Cmax,a (mg · liter−1) | 64 ± 67b | 27 | 12 | 171 |
| t1/2β,a (h) | 31.7 ± 39.4b | 21.8 | 2.8 | 108.2 |
| AUCa (mg · h · liter−1) | 1,458 ± 515b | 1,425 | 686 | 5,736 |
| AUC0-6,a (mg · h · liter−1) | 284 ± 330b | 98 | 18 | 787 |
| AUC0-8,a (mg · h · liter−1) | 368 ± 400b | 148 | 30 | 993 |
| AUC0-12,a (mg · h · liter−1) | 493 ± 464b | 248 | 60 | 1,359 |
| Cav(ss),a (mg · liter−1) | 182 ± 64b | 178 | 86 | 273 |
a
One patient had two abscesses.
b
In three pus samples, the Ca(ti) was less than the LOD. Parameters are presented only for patients for whom the Ca(ti) was greater than the LOD and whose terminal slope included at least three data points (n = 6).