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. 2025 Dec 9;15:7. doi: 10.1186/s13741-025-00637-2

Table 2.

Major complications in patients undergoing lumbar spine surgery

Perioperative complications Hypothyroidism N (%) Whole non-hypothyroidism N (%) P value Matched non-hypothyroidism N (%) P value
Medical complications
 Sepsis 768 (0.75%) 6,170 (0.79%) 0.127 1,410 (1.39%) < 0.001
 Postoperative shock 96 (0.09%) 665 (0.08%) 0.409 260 (0.26%) < 0.001
 Postoperative delirium 1,396 (1.37%) 6,663 (0.86%) < 0.001 2,109 (2.12%) < 0.001
 Acute cerebrovascular disease 1,035 (1.02%) 6,472 (0.84%) < 0.001 1,560 (1.53%) < 0.001
 Acute myocardial infarction 2,689 (2.64%) 18,927 (2.45%) < 0.001 3,137 (3.08%) < 0.001
 congestive heart failure 2,850 (2.81%) 13,566 (1.76%) < 0.001 4,547 (4.47%) < 0.001
 Deep vein thrombosis 507 (0.49%) 3,843 (0.50%) 1.000 867 (0.85%) < 0.001
 Pneumonia 1,352 (1.33%) 9,456 (1.23%) 0.005 2,253 (2.21%) < 0.001
 Pulmonary embolism 315 (0.31%) 2,246 (0.29%) 0.309 538 (0.53%) < 0.001
 Respiratory failure 1,532 (1.51%) 8,969 (1.16%) < 0.001 2,493 (2.45%) < 0.001
 Urinary tract infection 4,313 (4.24%) 21,452 (2.78%) < 0.001 5,439 (5.34%) < 0.001
 Transfusion 8,895 (8.74%) 45,972 (5.96%) < 0.001 11,173 (10.98%) < 0.001
Wound complications
 Wound infection 470 (0.46%) 3,681 (0.48%) 0.503 638 (0.63%) < 0.001
 Wound dehiscence 222 (0.22%) 1,614 (0.21%) 0.560 370 (0.36%) < 0.001
Other complications
 Deaths 168 (0.17%) 1,597 (0.21%) 0.005 457 (0.45%) < 0.001
 Prolonged LOS 39,032 (38.4%) 241,935 (31.37%) < 0.001 45,458 (44.67%) < 0.001