Table 2.

DIAGNOdent values at each timepoint by treatment group showing Temporal changes from baseline (T0) to 6 months (T3)

Group	Baseline (T0) Mean ± SD [95% CI]	1 Month (T1) Mean ± SD [95% CI]	3 Months (T2) Mean ± SD [95% CI]	6 Months (T3) Mean ± SD [95% CI]	Δ (T3 − T0) Mean [95% CI]	p-value †
Control (A)	10.4 ± 2.5 [8.7–12.2]	11.5 ± 2.5 [9.7–13.2]	12.2 ± 2.6 [10.3–14.1]	14.8 ± 2.6 [13.0–16.6]	+ 4.35 [3.77–4.93]	< 0.001
CPP-ACP (B)	12.3 ± 1.5 [11.3–13.4]	11.1 ± 1.6 [10.0–12.3]	9.9 ± 1.3 [9.0–10.8]	8.3 ± 1.2 [7.4–9.2]	−4.02 [− 4.47 to − 3.56]	< 0.001
nHAp (C)	12.1 ± 0.7 [11.6–12.6]	10.0 ± 0.9 [9.3–10.6]	8.8 ± 0.7 [8.2–9.3]	6.7 ± 0.6 [6.2–7.1]	−5.36 [− 5.99 to − 4.72]	< 0.001
Fluoride (D)	12.1 ± 0.9 [11.5–12.7]	9.7 ± 1.1 [9.0–10.5]	10.8 ± 1.0 [10.1–11.6]	7.6 ± 0.8 [7.0–8.1]	−4.45 [− 4.78 to − 4.11]	< 0.001