FIG. 5.

Absence of cross-reaction between VP4 fractions dissociated from CVB3 or CVB4 (CVB4E2) in the plasma-dependent enhancement of CVB-induced IFN-α production by PBMC. Plasma samples obtained from 5 healthy subjects (a) or 5 IDDM patients (b) were preincubated for 1 h at 37°C in the absence or presence of the VP4 fraction (1 μg/ml) dissociated from CVB3 or CVB4 (CVB4E2) before the addition of CVB3 or CVB4 (CVB4E2) (MOI, 1) for one additional hour at 37°C.