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. 2005 Nov;79(22):14031–14043. doi: 10.1128/JVI.79.22.14031-14043.2005

FIG. 3.

FIG. 3.

VV(Cop)ΔF1L induces apoptosis in Jurkat cells. (A) Jurkat cells were infected with VV(Cop) or VV(Cop)ΔF1L at an MOI of 10 for 15 h, and apoptosis was assessed by TMRE fluorescence. (B) Jurkat cells were infected with VV(Cop) or VV(Cop)ΔF1L at an MOI of 10 for 5, 10, and 15 h. Cytochrome c release and caspase 3 activation were monitored by Western blot analysis. (C) Bcl-2 overexpression is sufficient to inhibit VV(Cop)ΔF1L-induced apoptosis. Jurkat cells were infected with VV(Cop) or VV(Cop)ΔF1L at an MOI of 10 for 5, 10, and 15 h in the presence and absence of zVAD.fmk. Cytochrome c release and caspase 3 activation were monitored by Western blot analysis.

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