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. 2025 Dec 5;57(4):472–477. doi: 10.3947/ic.2025.0130

Table 2. Risk factors for severe COVID-19a .

High risk Asthma, cancer, cerebrovascular disease, chronic kidney disease, chronic lung diseases (bronchiectasis, chronic obstructive pulmonary disease, interstitial lung diseases, pulmonary embolism, pulmonary hypertension), chronic liver diseases (cirrhosis, non-alcoholic fatty liver disease, alcoholic liver disease, autoimmune hepatitis), cystic fibrosis, type 1 and type 2 diabetes, disabilitiesb (down syndrome, etc.), heart conditions (heart failure, coronary artery disease, cardiomyopathy), Human immunodeficiency virus infection, mental health conditions (mood disorders, schizophrenia spectrum disorders), dementia, Parkinson’s disease, obesity (body mass index [BMI] ≥30 or ≥95th percentile for children), physical inactivity, pregnancy and recent pregnancy, primary immunodeficiencies, current and former smoking, solid organ or blood stem cell transplantation, tuberculosis, use of corticosteroids or other immunosuppressive medications
Suggestive high risk Children with certain underlying conditionsb, epilepsy, hemophilia, overweight (25 ≤ BMI <30), sickle cell disease, substance use disorders
Inconclusive Alpha-1 antitrypsin deficiency, bronchopulmonary dysplasia, hepatitis B, hepatitis C, hypertension, thalassemia

aSource: United State Centers for Disease Control and Prevention [17].

bFor the complete list of disabilities classified as high-risk and the underlying conditions in children presumed to be high-risk, see reference [17].

COVID-19, coronavirus disease 2019.