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The negative effect of YY1 is also valid for the endogenous IFN-β gene. For human MG63 cells, the IFN-β gene is induced by NDV subsequent to transfection of 0, 0.3, and 0.5 μg of YY1 expression plasmid (right-hand columns). Interferon levels have been determined via the protection of an indicator cell line (Vero) from the cytopathogenic effects of VSV.
