TABLE 1.

Library of histone alleles engineered through site-directed mutagenesis

Histone	Residue	Modification	Substitutions
Histone H4	Lys 31	Acetylation	K31A, K31R, K31Q
	Ser 47	Phosphorylation	S47A, S47E
	Lys 59	Methylation	K59A, K59R, K59Q
	Lys 77	Acetylation	K77A, K77R, K77Q
	Lys 79	Acetylation/methylation	K79A, K79R, K79Q
	Lys 91	Acetylation	K91A, K91R, K91Q
	Arg 92	Methylation	R92A, R92K
Histone H3	Arg 52	Methylation	R52A, R52K, R52Q
	Arg 53	Methylation	R53A, R53K, R53Q
	Lys 56	Acetylation/methylation	K56A, K56R, K56Q
	Lys 79	Methylation	K79A, K79R, K79Q
	Lys 115	Acetylation	K115A, K115R, K115Q
	Thr 118	Phosphorylation	T118A, T118E
	Lys 122	Acetylation	K122A, K122R, K122Q