FIG. 2.

Histopathology of genital tract tissue of C57BL/6 female mice following infection with C. trachomatis (MoPn). Animals were infected as described in the legend for Fig. 1. (A to C) Uterine tissues stained with hematoxylin and eosin. (A) Noninfected. (B) Day 14 postinfection. (C) Day 42 postinfection. Note the marked thinning of the epithelial surface accompanied by an intense subacute inflammatory response consisting of polymorphonuclear cells, macrophages, and lymphocytes (B). The inflammatory response subsides as infection resolves (C). Localization of chlamydial inclusions to the epithelium was demonstrated by staining uterine tissue, obtained from mice at day 7 postinfection, with anti-MoPn MOMP immunoperoxidase (D). E, epithelium; L, lumen; I, chlamydial inclusion; SM, submucosae. Magnifications, ×100. This figure was adapted with permission from reference 61.