TABLE 1.

Cardiolipin content is reduced in Snca^−/− brain in the absence of changes in other major phospholipids and sphingolipids

Lipid	Lipid content (nmol/g) ± SD		P valuea
	WT (n = 6)	Snca−/− (n = 6)
Cardiolipin	995 ± 76	776 ± 87	0.001b
Phosphatidylglycerol	544 ± 191	419 ± 169	0.26c
Phosphatidic acid	664 ± 156	601 ± 211	0.57c
Phosphatidylethanolamine	17,502 ± 3,760	19,955 ± 3,289	0.26c
Phosphatidylinositol	2,067 ± 111	2,250 ± 242	0.14c
Phosphatidylserine	5,577 ± 1,240	6,061 ± 1,149	0.50c
Phosphatidylcholine	23,338 ± 1,937	24,945 ± 1,345	0.13c
Sphingomyelin	6,208 ± 830	6,040 ± 744	0.72c
Total	56,895 ± 5,666	61,048 ± 3,933	0.17c

^aTwo-sided t test, unequal population variance.

^bStatistical significance at the P < 0.00625 level, corresponding to a nominal significance of P < 0.05 under a conservative Bonferroni correction for multiple hypothesis testing involving eight phospholipid classes.

^cNot significant (P > 0.00625).