TABLE 2.

Acyl side chain content of brain phospholipids from WT and Snca^−/− mice

Phospholipid	Fatty acid	Side chain content (mol% ± SD)		P valuea
		WTd	Snca−/−e
Cardiolipin	Total SFA	20.2 ± 3.2	30.6 ± 2.6	<0.0001b
	Total MUFA	25.6 ± 1.5	23.2 ± 2.0	0.04c
	Total n-3 PUFA	23.5 ± 1.6	23.3 ± 3.9	0.91c
	Total n-6 PUFA	30.7 ± 3.0	23.0 ± 0.8	<0.0001b
Phosphatidylcholine	Total SFA	62.2 ± 1.8	56.7 ± 4.5	0.087c
	Total MUFA	20.9 ± 0.8	27.7 ± 1.0	<0.0001b
	Total n-3 PUFA	7.5 ± 0.5	6.2 ± 0.8	0.038c
	Total n-6 PUFA	9.6 ± 0.4	9.5 ± 1.35	0.89c
Phosphatidylethanolamine	Total SFA	24.6 ± 0.4	27.1 ± 1.0	0.011b
	Total MUFA	16.7 ± 1.6	17.1 ± 0.6	0.63c
	Total n-3 PUFA	37.0 ± 1.5	32.7 ± 1.7	0.007b
	Total n-6 PUFA	21.6 ± 1.0	23.3 ± 0.5	0.016c
Phosphatidylserine	Total SFA	44.2 ± 1.2	45.9 ± 1.6	0.13c
	Total MUFA	16.4 ± 0.5	16.8 ± 3.0	0.81c
	Total n-3 PUFA	32.7 ± 0.6	28.7 ± 2.8	0.062c
	Total n-6 PUFA	6.5 ± 0.26	7.4 ± 0.72	0.083c
Phosphatidylinositol	Total SFA	42.4 ± 1.2	44.5 ± 2.2	0.15c
	Total MUFA	10.7 ± 0.95	12.8 ± 1.5	0.06c
	Total n-3 PUFA	6.3 ± 0.51	4.6 ± 0.73	0.01b
	Total n-6 PUFA	40.8 ± 1.8	37.9 ± 2.8	0.13c

^aNominal P value under two-sided t test (not assuming equal population variances).

^bIndicates statistical significance at the P < 0.0125 level, corresponding to a nominal significance of P < 0.05 under a conservative Bonferroni correction for multiple hypothesis testing for each of the four types of fatty acids.

^cIndicates not significant (P > 0.0125).

^dFor cardiolipin, n = 6 WT mice; n = 5 WT mice for other phospholipids.

^eFor Snca^−/− mice, n = 6 for cardiolipin and n = 4 for the other phospholipids.