TABLE 3.
Reduced incorporation and turnover of palmitic and arachidonic acids into brain cardiolipin in mice lacking α-synuclein
| Parameter and FA | Mean response ± SD
|
% Change | P value | |
|---|---|---|---|---|
| WT | Snca−/− | |||
| Incorporation rate (nmol/h) | ||||
| Palmitic acid (16:0)a | 4.4 ± 2.3 | 2.1 ± 1.4 | −52 | 0.048 |
| Arachidonic acid (20:4 n-6)b | 76.7 ± 20.0 | 41.5 ± 12.7 | −46 | 0.013 |
| Fractional turnover (% h) | ||||
| Palmitic acid (16:0)a | 7.1 ± 2.7 | 3.4 ± 2.1 | −52 | 0.015 |
| Arachidonic acid (20:4 n-6)b | 54.1 ± 14.2 | 28.0 ± 7.3 | −48 | 0.010 |
| Half-life (h) | ||||
| Palmitic acid (16:0)a | 11.6 ± 5.3 | 21.3 ± 10.0 | 84 | 0.049 |
| Arachidonic acid (20:4 n-6)b | 1.4 ± 0.4 | 2.6 ± 0.7 | 86 | 0.014 |
a
Studies performed with seven pairs of mice.
b
Studies performed with five pairs of mice.