TABLE 1.
MICs (in micrograms/milliliter) of compounds during induction of yhcS antisense with or without ATc
| Compound and activity | WCUH29/pYH3
|
JSAS909
|
||
|---|---|---|---|---|
| Without ATc | With ATc (250 ng/ml) | Without ATc | With ATc (250 ng/ml) | |
| DNA synthesis | ||||
| Quinacrine 2 HCl | >64 | >64 | >64 | >64 |
| Novobiocin | 0.125 | 0.125 | 0.125 | 0.125 |
| RNA transcription | ||||
| Rifampin | 0.06 | 0.06 | 0.06 | 0.06 |
| Translation | ||||
| Chloramphenicol | 8 | 8 | 8 | 8 |
| Kanamycin | 64 | 64 | 64 | 64 |
| Erythromycin | >64 | >64 | >64 | >64 |
| Cell wall biosynthesis | ||||
| Phospomycin | 8 | 8 | 8 | 1 |
| Vancomycin | 0.5 | 1 | 1 | 0.5 |
| Bacitracin | >64 | >64 | >64 | >64 |
| Polymyxin B | >64 | >64 | >64 | >64 |
| Lipid biosynthesis | ||||
| Cerulenin | 64 | 64 | 64 | 64 |
| Electron transporter | ||||
| Oligomycin | >64 | >64 | >64 | >64 |